Acute Myeloid Leukemia with Brain Involvement (Chloroma)

Laryngeal chloroma heralding relapse of acute myeloid leukemia.

Introduction Granulocytic sarcomas, also referred to as chloromas or myeloid sarcomas, are extramedullary neoplasms that are composed of immature myeloidcells.Thetermchloromareferstothegreencolorthat is imparted to the tissues as a result of the high concentration of myeloperoxidase foundwithinthetumorcells. These tumors typicallyoccur inassociation with nonlymphocytic leukemias or myelodysplas...

Liver Involvement with Acute Myeloid Leukemia

Liver involvement with acute myeloid leukemia (AML) is rarely reported. The majority of published cases suggest a cholestatic picture and obstructive jaundice at presentation. On the contrary, our patient presented with transaminitis without cholestasis. Elevated liver function tests persisted in our patient despite cholecystectomy; however, they normalized with chemotherapy administration, sug...

KIR2DS3 is Associated with Protection against Acute Myeloid Leukemia

Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML;...

Chloroma of the testis in a patient with a history of acute myeloid leukemia

Chloroma, or granulocytic sarcoma, is a rare extramedullary solid hematologic cancer, found concomitant with acute myeloid leukemia. It is infrequently associated with other myeloproliferative disorders or chronic myelogenous leukemia. Chloroma of the testis after allogeneic bone marrow transplantation is particularly sparsely represented in the literature. It is suggested that an appropriate p...

Acute Myeloid Leukemia Presenting as Granulocytic Sarcoma (Chloroma) of the Tongue: A Case Report